Bowe won the 1995 and 1996 rounds, with the then-Dick Johnson Racing driver clean-sweeping the 1996 event.
Van Gisbergen became the sixth driver to win a sprint race in Bathurst, and the third Holden driver to do so.
Sunday's Race 2 was the 11th sprint race at Mount Panorama, with Ian Geoghegan and Bowe the most successful drivers with three wins each.
Van Gisbergen slots in behind with two, with Norm Beechey, Dick Johnson and Mark Skaife all one-time winners.
All six drivers are title winners, with Geoghegan, Johnson and Skaife all five-time champions.
Geoghegan's 1966 win also marked his second title, having won his first at Lakeside in 1964.
The weekend also marked the third instance of van Gisbergen sweeping a season-opening event, following his Adelaide doubles in 2017 and 2018.
However, precedent suggests van Gisbergen won't enjoy a cakewalk to the 2021 title; both times he swept the Adelaide event, he failed to go on to win the championship.
Van Gisbergen will continue his 2021 campaign at the Penrite Oil Sandown SuperSprint across March 20-21. Tickets are on sale now.