Reynolds and co-driver Luke Youlden dominated the 2018 Great Race, but Reynolds hit exhaustion late in the race, which let Lowndes and Steven Richards swoop and win.
Skaife tipped Reynolds as his dark horse, rather than outright title hope, and expressed optimism Tickford Racing will regroup from a tough 2018.
"I think Dave Reynolds will be one there," Skaife said.
"I think that performance of his at Bathurst, in terms of outright speed, was fantastic.
"There’s a couple. I’m hoping that Tickford will do better.
"So Chaz Mostert, I rate very highly, I anticipate that to work for Chaz. If that car’s better then he will be up there somewhere."
Skaife and Lowndes were HRT team-mates, then won Bathurst together with Triple Eight in 2010
Lowndes teams up with Whincup in the enduros, the pair having taken a hat-trick of Bathurst wins from 2006.
Skaife believes Whincup "will take some beating" as he looks to add an eighth title, in a likely fight against defending champ McLaughlin.
"There were times last year when he just had a pretty average run and it was not really due to his own mistakes, he should have just got a better result – the wheel falling off at Bathurst, for instance," Skaife said of Whincup.
"You just don’t see that team having those sorts of issues that regularly and, for me, you don’t win seven championships without having a really good perspective on how you win, so I anticipate him to be more in contention.
"But I actually think what is going to unfold is the continued maturity and continued growth from Scotty.
"I really recognised from him last year a really well-rounded racing driver.
"There were weekends where his racing was, from an experience stand point, definitely better.
"His qualifying is always strong, and the weekends when he has an issue, he finds ways to get back to the front and that’s what he was better at in 2018.
"I think 2019 is going to be a cracker between those guys."